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Michael Miller, Ph D, Microbiology Technical Services, LLC, Dunwoody, GA 30338. CDC and the National Institutes of Health addressed the topic in their publication Biosafety in Microbiological and Biomedical Laboratories, now in its 5th edition (BMBL-5).

In 2008, CDC convened a Blue Ribbon Panel of laboratory representatives from a variety of agencies, laboratory organizations, and facilities to review laboratory biosafety in diagnostic laboratories.

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Should any of the guidelines provided herein conflict with federal, state, or local laws or regulatory requirements, the laboratorian should defer to the federal, state, or local requirements.

Warde Medical Laboratory, Ann Arbor, MI The material in this report originated in the National Center for Emerging and Zoonotic Infectious Diseases, Beth P. Telephone: 678-428-6319; Fax: 770-396-0955; E-mail: [email protected] Summary Prevention of injuries and occupational infections in U. BMBL-5, however, was not designed to address the day-to-day operations of diagnostic laboratories in human and animal medicine.

The members of this panel recommended that biosafety guidelines be developed to address the unique operational needs of the diagnostic laboratory community and that they be science based and made available broadly.

These guidelines promote a culture of safety and include recommendations that supplement BMBL-5 by addressing the unique needs of the diagnostic laboratory.

A specific section for veterinary diagnostic laboratories addresses the veterinary issues not shared by other human laboratory departments.

Recommendations for all laboratories include use of Class IIA2 biological safety cabinets that are inspected annually; frequent hand washing; use of appropriate disinfectants, including dilutions of household bleach; dependence on risk assessments for many activities; development of written safety protocols that address the risks of chemicals in the laboratory; the need for negative airflow into the laboratory; areas of the laboratory in which use of gloves is optional or is recommended; and the national need for a central site for surveillance and nonpunitive reporting of laboratory incidents/exposures, injuries, and infections.

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